There's a recent thread on jetting for VM38's by gggGary. Look for it;
Using a single carburetor won't alter jetting requirements much, but you're gonna be fighting the double whammy of a big venturi and overlength intake runners. A 38 mm. carb with a throttle shaft and plate in the spigot is effectively smaller than a 38 mm. carb with an unrestricted venturi.