Yes, it could (probably would) create a lean condition. You can attack the cleaning from 2 points. You can spray cleaner (and blow through with compressed air) up through the pilot inlet on the bottom of the body and also through the mix screw hole. When coming at it from the mix screw hole, block the pilot jet hole and the mix screw outlet into the main bore so the cleaner is directed only out the 3 by-pass holes. When coming at it from the pilot inlet, block the mix screw hole and it's outlet into the main bore. When you're done with the carb cleaner, blow WD40 through the circuit to flush the remnants of the cleaner out.