That PDMS chain, even tho' it has CH3 hydrocarbons dangling off every elbow, is supposedly quite inert, low reactive, due to the tight bonding facilitated by the silicon core. But, a collection of chains CAN be infiltrated by some other organics (non-polar solvents), but not water (a polar solvent). So, it acts like petro greases, but, due to its inertness, doesn't unwantedly react and infuse itself into adjacent chemicals.
My understanding is that it's inert and safe on all variations of (natural) rubbers.
Beyond that, are the bewildering numbers of tests in those o-ring material compatibility charts...