A 21" rear with a skinny tire on it is not much bigger than an 18" rear with a 'normal' rear tire on it.
Case in point, the 300-21 Avon Speedmaster I'm putting on my Voodoo Vintage bike is 27.2" in diameter. The rear is getting a 400-18 Avon Safety Mileage which is 26.7" in diameter.
Only 1/2" difference. So if an 18" rear rim and typical tire will fit, so will a 21" front with a naturally smaller tire.