I was talking about tyre clearance
I'd like to see you replace a 16" wheel with an 18" wheel and retain the same chain.
Look the op asked for advice regarding decreasing the rpm at 70mph and 75mph on a trip up CA on the freeway .
He doesn't need to change his bluddy wheel
or his front sprocket or his chain unless they are worn. All he needs to do is a simple quick cheap and totally effective change of his rear sprocket to reduce the revs from 5000+rpm down to a more comfortable 4300rpm or similar.
You might find cruising at 5000rpm comfortable on a 35 year old twin but most of the rest of us wouldn't if there was a cheap alternative