That chart's a bit odd; generic NJ and needle in the VM36, for example, is Q2 (not Q5) and 6DP1 (not 6FJ6).
Anyway, gggGary, you'll give up performance down low and likely won't gain a thing up high with the 38's. You'll need to jet a tad richer on mains and pilots than you would on VM34's, but I'd guess that the combination of P-6 NJ and 6F9 needle would be what you'd want. With some carb/motor combinations the full-throttle mixture leans out at high rpm, and that condition is corrected with the main air correction jet; if you roll to WOT at, say, 4K rpm and get clean response, then try the same at 6.5K and get lean signals (motor falls on its face or misfires), you go to smaller MAJ's until it clears up. The 0.5 in the chart might be fine for some 2-stroke applications, but on our twins you should start with no correction, and if you get down to 1.9, look elsewhere for the misfire. As a baseline, I'd start with PJ: 25; MJ: 200; NJ: P-6; N: 6F9-3; PAJ: open.
Can those carbs be made to run well? I guess if "runs well" means they'll get you down the street without embarrassing misbehavior, yeah. But even with a big bore motor you can expect idle and off-idle operation to be just a little ragged with the 38's due to the weaker vacuum signal; you might try a pair of #2 slides if that's a problem and you want to throw a bunch of money at it. If you want better performance on a stocker than a good pair of BS38's will deliver, though, the big VM's won't give it to you, and IMO unless you have cables and a bunch of VM brass already on hand or are building a big bore drag bike or road racer (for fast tracks where you spend most of your time at WOT, not tight technical courses), the 38's probably aren't worth messing with.
Dogger, I've used VM36's on stock motors to baseline them before installing them on big bore motors. True, there's a slight hp loss down low as compared to the 34's, but it's nothing you'll feel in the seat of your pants. The problem is not in your carb selection but in the tuning. Exhaust selection is critical.